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Mycobacterium tuberculosis peptide E7/HLA-DRB1 tetramers with different HLA-DR alleles bound CD4(+) T cells might share identical CDR3 region

Human CD4(+) T cells play an important role in the immune response to Mycobacterium tuberculosis (MTB). However, little is known about the spectratyping characteristics of the CD4(+) T-cell receptor (TCR) α- and β-chains CDR3 region in tuberculosis (TB) patients. We sorted MTB peptide E7-bound CD4(+...

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Detalles Bibliográficos
Autores principales: Gan, Yichuan, Wang, Cong, Fang, Yimin, Yao, Yanan, Tu, Xiaoxin, Wang, Jiao, Huang, Xi, Tan, Yaoju, Chen, Tao, Zhang, Kouxing, Shen, Yanming, Zhou, Lin, Liu, Jianxiong, Lai, Xiaomin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028479/
https://www.ncbi.nlm.nih.gov/pubmed/29967390
http://dx.doi.org/10.1038/s41598-018-28344-7