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Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape

Voltage-dependent activation of voltage-gated cation channels results from the outward movement of arginine-bearing helices within proteinaceous voltage sensors. The voltage-sensing residues in potassium channels have been extensively characterized, but current functional approaches do not allow a d...

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Detalles Bibliográficos
Autores principales: Infield, Daniel T., Lee, Elizabeth E.L., Galpin, Jason D., Galles, Grace D., Bezanilla, Francisco, Ahern, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028492/
https://www.ncbi.nlm.nih.gov/pubmed/29866793
http://dx.doi.org/10.1085/jgp.201812075