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Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape
Voltage-dependent activation of voltage-gated cation channels results from the outward movement of arginine-bearing helices within proteinaceous voltage sensors. The voltage-sensing residues in potassium channels have been extensively characterized, but current functional approaches do not allow a d...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028492/ https://www.ncbi.nlm.nih.gov/pubmed/29866793 http://dx.doi.org/10.1085/jgp.201812075 |