Cargando…

Itraconazole targets cell cycle heterogeneity in colorectal cancer

Cellular dormancy and heterogeneity in cell cycle length provide important explanations for treatment failure after adjuvant therapy with S-phase cytotoxics in colorectal cancer (CRC), yet the molecular control of the dormant versus cycling state remains unknown. We sought to understand the molecula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buczacki, Simon J.A., Popova, Semiramis, Biggs, Emma, Koukorava, Chrysa, Buzzelli, Jon, Vermeulen, Louis, Hazelwood, Lee, Francies, Hayley, Garnett, Mathew J., Winton, Douglas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028508/ https://www.ncbi.nlm.nih.gov/pubmed/29853607 http://dx.doi.org/10.1084/jem.20171385

Ejemplares similares

Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition
por: Popova, Semiramis A., et al.
Publicado: (2018)

Use of preclinical models for malignant pleural mesothelioma
por: Shamseddin, Marie, et al.
Publicado: (2021)

Stem cells, quiescence and rectal carcinoma: an unexplored relationship and potential therapeutic target
por: Buczacki, S, et al.
Publicado: (2011)

Cell Model Passports—a hub for clinical, genetic and functional datasets of preclinical cancer models
por: van der Meer, Dieudonne, et al.
Publicado: (2019)

Repurposing antifungals: population pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of a nanocrystal formulation
por: Jansen, Anouk M E, et al.
Publicado: (2023)

475. Does Metabolite Matter? Defining Target Itraconazole and Hydroxy-itraconazole Serum Levels for Blastomycosis
por: Hess, Danielle, et al.
Publicado: (2022)

The Many Faces of Itraconazole Cardiac Toxicity
por: Teaford, Hilary R., et al.
Publicado: (2020)

Pharmacokinetic and clinical comparison of super-bioavailable itraconazole and conventional itraconazole at different dosing in dermatophytosis
por: Dhoot, Dhiraj, et al.
Publicado: (2023)

Tumour heterogeneity and evolutionary dynamics in colorectal cancer
por: Chan, Dedrick Kok Hong, et al.
Publicado: (2021)

Heart failure induced by itraconazole
por: Okuyan, Hızır, et al.
Publicado: (2013)

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
por: Li, Xiaodun, et al.
Publicado: (2018)

Induced Cell Cycle Arrest in Triple-Negative Breast Cancer by Combined Treatment of Itraconazole and Rapamycin
por: Wu, Hua-Tao, et al.
Publicado: (2022)

Mesothelial Cells Exhibit Characteristics of Perivascular Cells in an In Vitro Angiogenesis Assay
por: Koukorava, Chrysa, et al.
Publicado: (2023)

Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial
por: Shenoy, Manjunath M, et al.
Publicado: (2023)

Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells
por: Hu, Qiang, et al.
Publicado: (2017)

Candidiasis vulvovaginal tratamiento oral con itraconazol/
por: Rodriguez Serrano, Tiburcio Manuel
Publicado: (1993)

ORAL ITRACONAZOLE FOR THE TREATMENT OF SEVERE SEBORRHOEIC DERMATITIS
por: Das, Jayasri, et al.
Publicado: (2011)

Investigation of microemulsion system for transdermal delivery of itraconazole
por: Chudasama, Arpan, et al.
Publicado: (2011)

Effect of Itraconazole on the Pharmacokinetics of Diclofenac in Beagle Dogs
por: Al-Jenoobi, Fahad I.
Publicado: (2010)

Transcriptional profile of Paracoccidioides spp. in response to itraconazole
por: Neto, Benedito Rodrigues da Silva, et al.
Publicado: (2014)

Comparison between Itraconazole and Cotrimoxazole in the Treatment of Paracoccidiodomycosis
por: Cavalcante, Ricardo de Souza, et al.
Publicado: (2014)

Skin rash during treatment with generic itraconazole
por: De Vuono, Antonio, et al.
Publicado: (2014)

The Influence of Ionizing Radiation on Itraconazole in the Solid State
por: Dettlaff, Katarzyna, et al.
Publicado: (2014)

Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis
por: Brzezinski, Piotr, et al.
Publicado: (2017)

Chromoblastomycosis: tissue modifications during itraconazole treatment
por: Purim, Kátia Sheylla Malta, et al.
Publicado: (2017)

Dupilumab facial redness: Positive effect of itraconazole
por: de Beer, Fleur S.A., et al.
Publicado: (2019)

Itraconazole as a new pharmacotherapy method in haemangiomas
por: Gałązka, Przemysław, et al.
Publicado: (2022)

A Case of Laryngeal Cryptococcosis that Responded to Itraconazole
por: Maezumi, Sorane, et al.
Publicado: (2023)

Super Bioavailable Itraconazole and Its Place and Relevance in Recalcitrant Dermatophytosis: Revisiting Skin Levels of Itraconazole and Minimum Inhibitory Concentration Data
por: Sardana, Kabir, et al.
Publicado: (2021)

P080 Comparison of efficacy of innovator molecule of itraconazole with generic forms of itraconazole in treatment naïve subjects with chronic pulmonary aspergillosis
por: Sehgal, Inderpaul, et al.
Publicado: (2022)

Turning off the BCL-2 switch to prevent intestinal tumorigenesis
por: van der Heijden, Maartje, et al.
Publicado: (2016)

Ultra-performance liquid chromatography electrospray ionization–tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma
por: Dwivedi, Ashish, et al.
Publicado: (2014)

Efficacy of Super-Bioavailable Itraconazole and Conventional Itraconazole at Different Dosing Regimens in Glabrous Tinea Infection - A Randomized Clinical Trial [Corrigendum]
Publicado: (2023)

Knee joint biomechanics in transtibial amputees in gait, cycling, and elliptical training
por: Orekhov, Greg, et al.
Publicado: (2019)

Subcutaneous Basidiobolomycosis Treated Successfully with Oral Itraconazole: A Case Report
por: Chaudhari, Dixit G., et al.
Publicado: (2022)

The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
por: Policastro, Lucca R., et al.
Publicado: (2022)

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation
por: Uribe-Lewis, Santiago, et al.
Publicado: (2020)

Itraconazole associated quadriparesis and edema: a case report
por: Karadi, Rangaprasad L, et al.
Publicado: (2011)

Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole
por: Li, Ke, et al.
Publicado: (2019)

An instance of excellent response of subcutaneous zygomycosis to itraconazole monotherapy
por: Patro, Priyadarshini, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_010483ute9kcrci8j92vc68ka9