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Centrosome amplification disrupts renal development and causes cystogenesis

Centrosome number is tightly controlled to ensure proper ciliogenesis, mitotic spindle assembly, and cellular homeostasis. Centrosome amplification (the formation of excess centrosomes) has been noted in renal cells of patients and animal models of various types of cystic kidney disease. Whether thi...

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Detalles Bibliográficos
Autores principales: Dionne, Lai Kuan, Shim, Kyuhwan, Hoshi, Masato, Cheng, Tao, Wang, Jinzhi, Marthiens, Veronique, Knoten, Amanda, Basto, Renata, Jain, Sanjay, Mahjoub, Moe R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028550/
https://www.ncbi.nlm.nih.gov/pubmed/29895697
http://dx.doi.org/10.1083/jcb.201710019