Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering

Amorpha-4,11-diene synthase (ADS) cyclizes the substrate farnesyl pyrophosphate to produce amorpha-4,11-diene as a major product. This is considered the first committed and rate-limiting step in the biosynthesis of the antimalarial artemisinin. Here, we utilize a reported 3D model of ADS to perform...

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Detalles Bibliográficos
Autores principales: Abdallah, Ingy I., van Merkerk, Ronald, Klumpenaar, Esmée, Quax, Wim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028579/
https://www.ncbi.nlm.nih.gov/pubmed/29967474
http://dx.doi.org/10.1038/s41598-018-28177-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028579/
https://www.ncbi.nlm.nih.gov/pubmed/29967474
http://dx.doi.org/10.1038/s41598-018-28177-4

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