Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage

Background: Neuroprotection studies are generally unable to demonstrate efficacy in humans. Our specific hypothesis is that multiple pathophysiologic pathways, of variable importance, contribute to ischemic brain damage. As a corollary to this, we discuss the broad hypothesis that a multifaceted app...

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Detalles Bibliográficos
Autores principales: Kofke, William A., Ren, Yue, Augoustides, John G., Li, Hongzhe, Nathanson, Katherine, Siman, Robert, Meng, Qing Cheng, Bu, Weiming, Yandrawatthana, Sukanya, Kositratna, Guy, Kim, Cecilia, Bavaria, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028620/
https://www.ncbi.nlm.nih.gov/pubmed/29997569
http://dx.doi.org/10.3389/fneur.2018.00497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028620/
https://www.ncbi.nlm.nih.gov/pubmed/29997569
http://dx.doi.org/10.3389/fneur.2018.00497

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