Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer’s Disease Mouse Model

One characteristic of Alzheimer’s disease (AD) is excessive accumulation of amyloid-β (Aβ) in the brain. Aβ brain accumulation is, in part, due to a reduction in Aβ clearance from the brain across the blood-brain barrier. One key element that contributes to Aβ brain clearance is P-glycoprotein (P-gp...

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Detalles Bibliográficos
Autores principales: Hartz, Anika M. S., Zhong, Yu, Shen, Andrew N., Abner, Erin L., Bauer, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028735/
https://www.ncbi.nlm.nih.gov/pubmed/29997495
http://dx.doi.org/10.3389/fnagi.2018.00186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028735/
https://www.ncbi.nlm.nih.gov/pubmed/29997495
http://dx.doi.org/10.3389/fnagi.2018.00186

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