Molecular dynamics simulations suggest why the A2058G mutation in 23S RNA results in bacterial resistance against clindamycin

Clindamycin, a lincosamide antibiotic, binds to 23S ribosomal RNA and inhibits protein synthesis. The A2058G mutation in 23S RNA results in bacterial resistance to clindamycin. To understand the influence of this mutation on short-range interactions of clindamycin with 23S RNA, we carried out full-a...

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Detalles Bibliográficos
Autores principales: Kulczycka-Mierzejewska, Katarzyna, Sadlej, Joanna, Trylska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028897/
https://www.ncbi.nlm.nih.gov/pubmed/29971530
http://dx.doi.org/10.1007/s00894-018-3689-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028897/
https://www.ncbi.nlm.nih.gov/pubmed/29971530
http://dx.doi.org/10.1007/s00894-018-3689-5

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