Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells

BACKGROUND: Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV) binding to CD4+ T cells, a signal transduction cascade is initiated that reorganizes the actin cytoskeleton, activates transcription...

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Detalles Bibliográficos
Autores principales: Wiredja, Danica D., Tabler, Caroline O., Schlatzer, Daniela M., Li, Ming, Chance, Mark R., Tilton, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029029/
https://www.ncbi.nlm.nih.gov/pubmed/29970186
http://dx.doi.org/10.1186/s12977-018-0423-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029029/
https://www.ncbi.nlm.nih.gov/pubmed/29970186
http://dx.doi.org/10.1186/s12977-018-0423-4

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