Cargando…

Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells

BACKGROUND: Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV) binding to CD4+ T cells, a signal transduction cascade is initiated that reorganizes the actin cytoskeleton, activates transcription...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiredja, Danica D., Tabler, Caroline O., Schlatzer, Daniela M., Li, Ming, Chance, Mark R., Tilton, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029029/ https://www.ncbi.nlm.nih.gov/pubmed/29970186 http://dx.doi.org/10.1186/s12977-018-0423-4

Ejemplares similares

HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells
por: Lucera, Mark B., et al.
Publicado: (2017)

CoPhosK: A method for comprehensive kinase substrate annotation using co-phosphorylation analysis
por: Ayati, Marzieh, et al.
Publicado: (2019)

Sequential CCR5-Tropic HIV-1 Reactivation from Distinct Cellular Reservoirs following Perturbation of Elite Control
por: Watters, Sarah A., et al.
Publicado: (2016)

Growth potentials of CCR5-tropic/CXCR4-tropic HIV-1mt clones in macaque cells
por: Doi, Naoya, et al.
Publicado: (2013)

CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro
por: Wu, Lijun, et al.
Publicado: (1997)

Inhibition of Dual/Mixed Tropic HIV-1 Isolates by CCR5-Inhibitors in Primary Lymphocytes and Macrophages
por: Surdo, Matteo, et al.
Publicado: (2013)

CXCR4- and CCR5-Tropic HIV-1 Clones Are Both Tractable to Grow in Rhesus Macaques
por: Doi, Naoya, et al.
Publicado: (2018)

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1
por: Itell, Hannah L., et al.
Publicado: (2023)

CCR5 Inhibitors and HIV-1 Infection
por: Latinovic, Olga S., et al.
Publicado: (2019)

Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines
por: Moody, M. Anthony, et al.
Publicado: (2010)

Pharmacokinetics, Safety and Efficacy of Maraviroc in Treatment-experienced Pediatric Patients Infected With CCR5-Tropic HIV-1
por: Giaquinto, Carlo, et al.
Publicado: (2018)

Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection
por: Harms, Mirja, et al.
Publicado: (2023)

Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2
por: Suzuki, Toru, et al.
Publicado: (2022)

Unique profile of predominant CCR5-tropic in CRF07_BC HIV-1 infections and discovery of an unusual CXCR4-tropic strain
por: Hu, Xiaoyan, et al.
Publicado: (2022)

Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties
por: Vacchini, Alessandro, et al.
Publicado: (2022)

Integrating phosphoproteomics in systems biology
por: Liu, Yu, et al.
Publicado: (2014)

Development of a CCR5-tropic HIV-1 fusion inhibition assay amenable to high-throughput screening for topical microbicides
por: Beer, B, et al.
Publicado: (2006)

Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia Virus
por: Weinstein, Raymond S, et al.
Publicado: (2010)

Macrocyclic polyamines inhibit HIV infection by interacting with the cellular HIV co-receptors CXCR4 and CCR5
por: Schols, Dominique, et al.
Publicado: (2009)

Targeting CCR5 trafficking to inhibit HIV-1 infection
por: Boncompain, Gaelle, et al.
Publicado: (2019)

Proteomic and Phosphoproteomic Reprogramming in Epithelial Ovarian Cancer Metastasis
por: Frederick, Mallory I., et al.
Publicado: (2023)

Identification of a CCR5-Expressing T Cell Subset That Is Resistant to R5-Tropic HIV Infection
por: Oswald-Richter, Kyra, et al.
Publicado: (2007)

Monophylogenetic HIV-1C epidemic in Ethiopia is dominated by CCR5-tropic viruses–an analysis of a prospective country-wide cohort
por: Kalu, Amare Worku, et al.
Publicado: (2017)

Maraviroc – A CCR5 Antagonist for the Treatment of HIV-1 Infection
por: Van Der Ryst, Elna
Publicado: (2015)

CCR5 structural plasticity shapes HIV-1 phenotypic properties
por: Colin, Philippe, et al.
Publicado: (2018)

Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy
por: Mohamed, Hager, et al.
Publicado: (2022)

CCR5Δ32 Genotypes in a German HIV-1 Seroconverter Cohort and Report of HIV-1 Infection in a CCR5Δ32 Homozygous Individual
por: Oh, Djin-Ye, et al.
Publicado: (2008)

Characterizing the Diverse Mutational Pathways Associated with R5-Tropic Maraviroc Resistance: HIV-1 That Uses the Drug-Bound CCR5 Coreceptor
por: Jiang, Xiaowei, et al.
Publicado: (2015)

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype
por: Song, Hongshuo, et al.
Publicado: (2023)

Phosphoproteomics: new insights into cellular signaling
por: Mumby, Marc, et al.
Publicado: (2005)

Pharmacophore-Oriented Identification of Potential Leads as CCR5 Inhibitors to Block HIV Cellular Entry
por: Singh, Pooja, et al.
Publicado: (2022)

Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians
por: Malhotra, Rakhi, et al.
Publicado: (2011)

Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates
por: Visseaux, Benoit, et al.
Publicado: (2015)

In vitro study of the trans-epithelial crossing of HIV-1 through the female genital mucosa and of the role of epithelial cells in the selection of CCR5-tropic virus
por: Terrasse, R, et al.
Publicado: (2012)

Endocytosis and Recycling of the HIV Coreceptor Ccr5
por: Signoret, Nathalie, et al.
Publicado: (2000)

Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry
por: Berro, Reem, et al.
Publicado: (2009)

Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV
por: Ankrom, Wendy, et al.
Publicado: (2021)

Expansion of Activated Memory CD4(+) T Cells Affects Infectivity of CCR5-Tropic HIV-1 in Humanized NOD/SCID/JAK3(null) Mice
por: Terahara, Kazutaka, et al.
Publicado: (2013)

Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s
por: Nakata, Hirotomo, et al.
Publicado: (2019)

V3 Loop Sequence Space Analysis Suggests Different Evolutionary Patterns of CCR5- and CXCR4-Tropic HIV
por: Bozek, Katarzyna, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_30uommivakdm927ng3o8gr1oeo