Cargando…

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

BACKGROUND: Autologous bone-marrow-derived cells are currently employed in clinical studies of cell-based therapy in multiple sclerosis (MS) although the bone marrow microenvironment and marrow-derived cells isolated from patients with MS have not been extensively characterised. OBJECTIVES: To exami...

Descripción completa

Detalles Bibliográficos
Autores principales:	Redondo, Juliana, Sarkar, Pamela, Kemp, Kevin, Virgo, Paul F, Pawade, Joya, Norton, Aimie, Emery, David C, Guttridge, Martin G, Marks, David I, Wilkins, Alastair, Scolding, Neil J, Rice, Claire M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Original Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029147/ https://www.ncbi.nlm.nih.gov/pubmed/28548004 http://dx.doi.org/10.1177/1352458517711276

Ejemplares similares

Repeat infusion of autologous bone marrow cells in multiple sclerosis: protocol for a phase I extension study (SIAMMS-II)
por: Rice, Claire M, et al.
Publicado: (2015)

Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis
por: Sarkar, Pamela, et al.
Publicado: (2018)

Purkinje Cell Pathology and Loss in Multiple Sclerosis Cerebellum
por: Redondo, Juliana, et al.
Publicado: (2014)

Assessment of bone marrow-derived Cellular Therapy in progressive Multiple Sclerosis (ACTiMuS): study protocol for a randomised controlled trial
por: Rice, Claire M., et al.
Publicado: (2015)

Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis
por: Redondo, Juliana, et al.
Publicado: (2018)

Reductions in kinesin expression are associated with nitric oxide-induced axonal damage
por: Redondo, Juliana, et al.
Publicado: (2015)

Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice
por: Kemp, Kevin C., et al.
Publicado: (2018)

An open-label pilot study of recombinant granulocyte-colony stimulating factor in Friedreich’s ataxia
por: Kemp, Kevin C., et al.
Publicado: (2022)

Cell fusion in the brain: two cells forward, one cell back
por: Kemp, Kevin, et al.
Publicado: (2014)

Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia
por: Kemp, Kevin C., et al.
Publicado: (2016)

Erratum to: ‘Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia’
por: Kemp, Kevin C., et al.
Publicado: (2016)

Aberrant cerebellar Purkinje cell function repaired in vivo by fusion with infiltrating bone marrow-derived cells
por: Kemp, Kevin C., et al.
Publicado: (2018)

Mechanisms of Oxidative Damage in Multiple Sclerosis and a Cell Therapy Approach to Treatment
por: Witherick, Jonathan, et al.
Publicado: (2010)

GMP-Compliant Isolation and Large-Scale Expansion of Bone Marrow-Derived MSC
por: Fekete, Natalie, et al.
Publicado: (2012)

The PPAR-gamma agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function
por: Gray, Elizabeth, et al.
Publicado: (2012)

Mesenchymal Stem Cell-Derived Factors Restore Function to Human Frataxin-Deficient Cells
por: Kemp, Kevin, et al.
Publicado: (2017)

Expansion and Harvesting of hMSC-TERT
por: Weber, Christian, et al.
Publicado: (2007)

Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection
por: Sarkar, Pamela, et al.
Publicado: (2021)

Mesenchymal Stem Cells Restore Frataxin Expression and Increase Hydrogen Peroxide Scavenging Enzymes in Friedreich Ataxia Fibroblasts
por: Kemp, Kevin, et al.
Publicado: (2011)

Alemtuzumab-based therapy for Secondary Malignant Histiocytosis arising from Pre-B-ALL
por: Abid, Muhammad Bilal, et al.
Publicado: (2017)

Significant improvement of bone marrow-derived MSC expansion from MDS patients by defined xeno-free medium
por: Altrock, Eva, et al.
Publicado: (2023)

Quantitative proteomic characterization of lung-MSC and bone marrow-MSC using DIA-mass spectrometry
por: Rolandsson Enes, Sara, et al.
Publicado: (2017)

Cytokine therapy‐mediated neuroprotection in a Friedreich's ataxia mouse model
por: Kemp, Kevin C., et al.
Publicado: (2017)

KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis
por: Hares, Kelly, et al.
Publicado: (2021)

MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC
por: Rolandsson Enes, Sara, et al.
Publicado: (2016)

Approaches for automized expansion and differentiation of human MSC in specialized bioreactors
por: Neumann, Anne, et al.
Publicado: (2013)

MSC Therapy Attenuates Obliterative Bronchiolitis after Murine Bone Marrow Transplant
por: Raza, Kashif, et al.
Publicado: (2014)

Safety assessment of bone marrow derived MSC grown in platelet-rich plasma
por: Fukuda, Shoji, et al.
Publicado: (2015)

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
por: Ho, Ya-Hsuan, et al.
Publicado: (2019)

Case report: Primary bone lymphoma presenting as a painful supraclavicular lump
por: Davies, Sian, et al.
Publicado: (2021)

Erdheim–Chester disease presenting as large vessel vasculitis
por: Ahmed, Azeem, et al.
Publicado: (2023)

The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche
por: Takam Kamga, Paul, et al.
Publicado: (2021)

A Conceptual Approach for Examining Effects of the Adolescent Bone Marrow Milieu on MSC Phenotype
por: Kannikeswaran, Sanjana, et al.
Publicado: (2023)

Percutaneous Endoscopic Gastrostomy Tube Insertion in Neurodegenerative Disease: A Retrospective Study and Literature Review
por: Sarkar, Pamela, et al.
Publicado: (2017)

Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labor
por: Alzamil, Hana A., et al.
Publicado: (2014)

Cotransplanted Bone Marrow Derived Mesenchymal Stem Cells (MSC) Enhanced Engraftment of Hematopoietic Stem Cells in a MSC-dose Dependent Manner in NOD/SCID Mice
por: Kim, Dong Hyun, et al.
Publicado: (2006)

Bone Marrow MSC Secretome Increases Equine Articular Chondrocyte Collagen Accumulation and Their Migratory Capacities
por: Contentin, Romain, et al.
Publicado: (2022)

Toward a serum-free, xeno-free culture system for optimal growth and expansion of hMSC suited to therapeutic applications
por: Genser-Nir, Mira, et al.
Publicado: (2013)

Predicting and Promoting Human Bone Marrow MSC Chondrogenesis by Way of TGFβ Receptor Profiles: Toward Personalized Medicine
por: Rothweiler, René, et al.
Publicado: (2020)

Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators
por: Holt, Vance, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gh8gg9lq43kjisdb5icsk2rcd5