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Proteolytic maturation of α(2)δ controls the probability of synaptic vesicular release

Auxiliary α(2)δ subunits are important proteins for trafficking of voltage-gated calcium channels (Ca(V)) at the active zones of synapses. We have previously shown that the post-translational proteolytic cleavage of α(2)δ is essential for their modulatory effects on the trafficking of N-type (Ca(V)2...

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Detalles Bibliográficos
Autores principales: Ferron, Laurent, Kadurin, Ivan, Dolphin, Annette C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029843/
https://www.ncbi.nlm.nih.gov/pubmed/29916807
http://dx.doi.org/10.7554/eLife.37507