Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase

Type II topoisomerases alter DNA topology to control DNA supercoiling and chromosome segregation and are targets of clinically important anti-infective and anticancer therapeutics. They act as ATP-operated clamps to trap a DNA helix and transport it through a transient break in a second DNA. Here, w...

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Detalles Bibliográficos
Autores principales: Laponogov, Ivan, Pan, Xiao-Su, Veselkov, Dennis A., Skamrova, Galyna B., Umrekar, Trishant R., Fisher, L. Mark, Sanderson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030046/
https://www.ncbi.nlm.nih.gov/pubmed/29968711
http://dx.doi.org/10.1038/s41467-018-05005-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030046/
https://www.ncbi.nlm.nih.gov/pubmed/29968711
http://dx.doi.org/10.1038/s41467-018-05005-x

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