Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Farnesoid-X-Receptor (FXR) plays a central role in maintaining bile acid (BA) homeostasis by transcriptional control of numerous enterohepatic genes, including intestinal FGF19, a hormone that strongly represses hepatic BA synthesis. How activation of the FGF19 receptor at the membrane is transmitte...

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Detalles Bibliográficos
Autores principales: Byun, Sangwon, Kim, Dong-Hyun, Ryerson, Daniel, Kim, Young-Chae, Sun, Hao, Kong, Bo, Yau, Peter, Guo, Grace, Xu, H. Eric, Kemper, Byron, Kemper, Jongsook Kim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030054/
https://www.ncbi.nlm.nih.gov/pubmed/29968724
http://dx.doi.org/10.1038/s41467-018-04697-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030054/
https://www.ncbi.nlm.nih.gov/pubmed/29968724
http://dx.doi.org/10.1038/s41467-018-04697-5

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