Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor

The physiological consequences of COX-2 overexpression in the development of cancer, diabetes and neurodegenerative diseases have made this enzyme a promising therapeutic target. Herein, COX-2 active site was analyzed and new molecules were designed. We identified a highly potent molecule (S)-3a wit...

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Detalles Bibliográficos
Autores principales: Singh, Palwinder, Kaur, Jagroop, Kaur, Harpreet, Kaur, Anudeep, Bhatti, Rajbir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030096/
https://www.ncbi.nlm.nih.gov/pubmed/29968808
http://dx.doi.org/10.1038/s41598-018-28408-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030096/
https://www.ncbi.nlm.nih.gov/pubmed/29968808
http://dx.doi.org/10.1038/s41598-018-28408-8

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