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Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor
The physiological consequences of COX-2 overexpression in the development of cancer, diabetes and neurodegenerative diseases have made this enzyme a promising therapeutic target. Herein, COX-2 active site was analyzed and new molecules were designed. We identified a highly potent molecule (S)-3a wit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030096/ https://www.ncbi.nlm.nih.gov/pubmed/29968808 http://dx.doi.org/10.1038/s41598-018-28408-8 |