Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates

Autolysosomal dysfunction and unstable microtubules are hallmarks of chronic neurodegenerative diseases associated with misfolded proteins. Investigation of impaired protein quality control and clearance systems could therefore provide an important avenue for intervention. To investigate this we hav...

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Detalles Bibliográficos
Autores principales: Phadwal, Kanchan, Kurian, Dominic, Salamat, Muhammad Khalid F., MacRae, Vicky E., Diack, Abigail B., Manson, Jean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030104/
https://www.ncbi.nlm.nih.gov/pubmed/29968775
http://dx.doi.org/10.1038/s41598-018-28296-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030104/
https://www.ncbi.nlm.nih.gov/pubmed/29968775
http://dx.doi.org/10.1038/s41598-018-28296-y

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