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Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates
Autolysosomal dysfunction and unstable microtubules are hallmarks of chronic neurodegenerative diseases associated with misfolded proteins. Investigation of impaired protein quality control and clearance systems could therefore provide an important avenue for intervention. To investigate this we hav...
Autores principales: | Phadwal, Kanchan, Kurian, Dominic, Salamat, Muhammad Khalid F., MacRae, Vicky E., Diack, Abigail B., Manson, Jean C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030104/ https://www.ncbi.nlm.nih.gov/pubmed/29968775 http://dx.doi.org/10.1038/s41598-018-28296-y |
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