Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats

Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark of Parkinson’s disease (PD). Here we investigate how chronic dopamine denervation and dopamine replacement with L-DOPA affect the morphology and physiology of direct pathway SPNs (dSPNS) in the rat striatum....

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Detalles Bibliográficos
Autores principales: Fieblinger, T., Zanetti, L., Sebastianutto, I., Breger, L. S., Quintino, L., Lockowandt, M., Lundberg, C., Cenci, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030109/
https://www.ncbi.nlm.nih.gov/pubmed/29968767
http://dx.doi.org/10.1038/s41598-018-28273-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030109/
https://www.ncbi.nlm.nih.gov/pubmed/29968767
http://dx.doi.org/10.1038/s41598-018-28273-5

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