A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links

Interstrand DNA cross-links (ICLs) block both replication and transcription, and are commonly repaired by the Fanconi anemia (FA) pathway. However, FA-independent repair mechanisms of ICLs remain poorly understood. Here we report a previously uncharacterized protein, SAN1, as a 5′ exonuclease that a...

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Detalles Bibliográficos
Autores principales: Andrews, Alex M., McCartney, Heather J., Errington, Tim M., D’Andrea, Alan D., Macara, Ian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030175/
https://www.ncbi.nlm.nih.gov/pubmed/29968717
http://dx.doi.org/10.1038/s41467-018-05008-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030175/
https://www.ncbi.nlm.nih.gov/pubmed/29968717
http://dx.doi.org/10.1038/s41467-018-05008-8

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