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A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links
Interstrand DNA cross-links (ICLs) block both replication and transcription, and are commonly repaired by the Fanconi anemia (FA) pathway. However, FA-independent repair mechanisms of ICLs remain poorly understood. Here we report a previously uncharacterized protein, SAN1, as a 5′ exonuclease that a...
Autores principales: | Andrews, Alex M., McCartney, Heather J., Errington, Tim M., D’Andrea, Alan D., Macara, Ian G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030175/ https://www.ncbi.nlm.nih.gov/pubmed/29968717 http://dx.doi.org/10.1038/s41467-018-05008-8 |
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