Impaired Myofilament Contraction Drives Right Ventricular Failure Secondary to Pressure Overload: Model Simulations, Experimental Validation, and Treatment Predictions

Introduction: Pulmonary hypertension (PH) causes pressure overload leading to right ventricular failure (RVF). Myocardial structure and myocyte mechanics are altered in RVF but the direct impact of these cellular level factors on organ level function remain unclear. A computational model of the card...

Descripción completa

Detalles Bibliográficos
Autores principales: Philip, Jennifer L., Pewowaruk, Ryan J., Chen, Claire S., Tabima, Diana M., Beard, Daniel A., Baker, Anthony J., Chesler, Naomi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030352/
https://www.ncbi.nlm.nih.gov/pubmed/29997518
http://dx.doi.org/10.3389/fphys.2018.00731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030352/
https://www.ncbi.nlm.nih.gov/pubmed/29997518
http://dx.doi.org/10.3389/fphys.2018.00731

Ejemplares similares