Coexpression of p-IGF-1R and MMP-7 Modulates Panitumumab and Cetuximab Efficacy in RAS Wild-Type Metastatic Colorectal Cancer Patients

INTRODUCTION: The coexpression of pIGF-1R and MMP-7 (double-positive phenotype, DP) correlates with poor overall survival (OS) in KRAS wild-type (WT) (exon 2) metastatic colorectal cancer (mCRC) patients treated with irinotecan-cetuximab in second/third line. METHODS: We analyzed two prospective bio...

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Detalles Bibliográficos
Autores principales: Alonso, Vicente, Escudero, Pilar, Fernández-Martos, Carlos, Salud, Antonia, Méndez, Miguel, Gallego, Javier, Rodriguez, Jose-R., Martín-Richard, Marta, Fernández-Plana, Julen, Manzano, Hermini, Méndez, José-Carlos, Zanui, Monserrat, Falcó, Esther, Gil-Raga, Mireia, Rojo, Federico, Cuatrecasas, Miriam, Feliu, Jaime, García-Albéniz, Xabier, Maurel, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030389/
https://www.ncbi.nlm.nih.gov/pubmed/29842993
http://dx.doi.org/10.1016/j.neo.2018.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030389/
https://www.ncbi.nlm.nih.gov/pubmed/29842993
http://dx.doi.org/10.1016/j.neo.2018.05.004

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