Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2()

The anticancer drug temozolomide is the only drug with proven activity against high-grade gliomas and has therefore become a part of the standard treatment of these tumors. P-glycoprotein (P-gp; ABCB1) and breast cancer resistance protein (BCRP; ABCG2) are transport proteins, which are present at th...

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Detalles Bibliográficos
Autores principales: de Gooijer, Mark C., de Vries, Nienke A., Buckle, Tessa, Buil, Levi C.M., Beijnen, Jos H., Boogerd, Willem, van Tellingen, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030392/
https://www.ncbi.nlm.nih.gov/pubmed/29852323
http://dx.doi.org/10.1016/j.neo.2018.05.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030392/
https://www.ncbi.nlm.nih.gov/pubmed/29852323
http://dx.doi.org/10.1016/j.neo.2018.05.001

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