Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

As oxygen is essential for many metabolic pathways, tumor hypoxia may impair cancer cell proliferation (1–4). However, the limiting metabolites for proliferation under hypoxia and in tumors are unknown. Here, we assessed proliferation of a collection of cancer cells upon inhibition of the mitochondr...

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Detalles Bibliográficos
Autores principales: Garcia-Bermudez, Javier, Baudrier, Lou, La, Konnor, Zhu, Xiphias Ge, Fidelin, Justine, Sviderskiy, Vladislav O, Papagiannakopoulos, Thales, Molina, Henrik, Snuderl, Matija, Lewis, Caroline A., Possemato, Richard L., Birsoy, Kıvanç
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030478/
https://www.ncbi.nlm.nih.gov/pubmed/29941933
http://dx.doi.org/10.1038/s41556-018-0118-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030478/
https://www.ncbi.nlm.nih.gov/pubmed/29941933
http://dx.doi.org/10.1038/s41556-018-0118-z

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