Towards conformational fidelity of a quaternary HIV-1 epitope: computational design and directed evolution of a minimal V1V2 antigen

Structure-based approaches to antigen design utilize insights from antibody (Ab):antigen interactions and a refined understanding of protective Ab responses to engineer novel antigens presenting epitopes with conformations relevant to eliciting or discovering protective humoral responses. For human...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Jennifer I, Verma, Deeptak, Bailey-Kellogg, Chris, Ackerman, Margaret E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030936/
https://www.ncbi.nlm.nih.gov/pubmed/29897567
http://dx.doi.org/10.1093/protein/gzy010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030936/
https://www.ncbi.nlm.nih.gov/pubmed/29897567
http://dx.doi.org/10.1093/protein/gzy010

Ejemplares similares