Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine

INTRODUCTION: Berberine (BBR) is a plant-derived benzylisoquinoline alkaloid and has been demonstrated to be a potential treatment for various chronic diseases. The poor water solubility and P-glycoprotein (Pgp)-mediated drug efflux are the main challenges for its further application in a clinical s...

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Detalles Bibliográficos
Autores principales: Xiong, Wei, Sang, Wei, Linghu, Ke Gang, Zhong, Zhang Feng, Cheang, Wai San, Li, Juan, Hu, Yuan Jia, Yu, Hua, Wang, Yi Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030940/
https://www.ncbi.nlm.nih.gov/pubmed/29988733
http://dx.doi.org/10.2147/IJN.S163763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030940/
https://www.ncbi.nlm.nih.gov/pubmed/29988733
http://dx.doi.org/10.2147/IJN.S163763

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