Brain PET Imaging of α7-nAChR with [18F]ASEM: Reproducibility, Occupancy, Receptor Density, and Changes in Schizophrenia

BACKGROUND: The α7 nicotinic acetylcholine receptor increasingly has been implicated in normal brain physiology, as well as in neuropsychiatric disorders. The highly cortical distribution of α7 nicotinic acetylcholine receptor suggests a role in cognition. METHODS: We expanded the first-in-human PET...

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Detalles Bibliográficos
Autores principales: Wong, Dean F, Kuwabara, Hiroto, Horti, Andrew G, Roberts, Joshua M, Nandi, Ayon, Cascella, Nicola, Brasic, James, Weerts, Elise M, Kitzmiller, Kelly, Phan, Jenny A, Gapasin, Lorena, Sawa, Akira, Valentine, Heather, Wand, Gary, Mishra, Chakradhar, George, Noble, McDonald, Michael, Lesniak, Wojtek, Holt, Daniel P, Azad, Babak B, Dannals, Robert F, Kem, William, Freedman, Robert, Gjedde, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030963/
https://www.ncbi.nlm.nih.gov/pubmed/29522184
http://dx.doi.org/10.1093/ijnp/pyy021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030963/
https://www.ncbi.nlm.nih.gov/pubmed/29522184
http://dx.doi.org/10.1093/ijnp/pyy021

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