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Cancer progression models and fitness landscapes: a many-to-many relationship
MOTIVATION: The identification of constraints, due to gene interactions, in the order of accumulation of mutations during cancer progression can allow us to single out therapeutic targets. Cancer progression models (CPMs) use genotype frequency data from cross-sectional samples to identify these con...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031050/ https://www.ncbi.nlm.nih.gov/pubmed/29048486 http://dx.doi.org/10.1093/bioinformatics/btx663 |