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Staging of amyloid β, t-tau, regional atrophy rates, and cognitive change in a nondemented cohort: Results of serial mediation analyses

INTRODUCTION: Current models posit a sequence of amyloid β (Aβ), tau, atrophy, and cognitive change leading to Alzheimer's disease, but ambiguities remain. We examined these sequences via serial mediations. METHODS: We studied normal controls, early mild cognitive impairment, and late mild cogn...

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Detalles Bibliográficos
Autores principales: Fletcher, Evan, Filshtein, Teresa Jenica, Harvey, Danielle, Renaud, Alice, Mungas, Dan, DeCarli, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031152/
https://www.ncbi.nlm.nih.gov/pubmed/29984299
http://dx.doi.org/10.1016/j.dadm.2018.04.001