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The transcription factor Grainyhead primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes
Transcriptional enhancers function as docking platforms for combinations of transcription factors to control gene expression. How enhancer sequences determine nucleosome occupancy, transcription factor recruitment, and transcriptional activation in vivo remains unclear. Using ATAC-seq across a panel...
Autores principales: | Jacobs, Jelle, Atkins, Mardelle, Davie, Kristofer, Imrichova, Hana, Romanelli, Lucia, Christiaens, Valerie, Hulselmans, Gert, Potier, Delphine, Wouters, Jasper, Taskiran, Ibrahim Ihsan, Paciello, Giulia, González-Blas, Carmen Bravo, Koldere, Duygu, Aibar, Sara, Halder, Georg, Aerts, Stein |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031307/ https://www.ncbi.nlm.nih.gov/pubmed/29867222 http://dx.doi.org/10.1038/s41588-018-0140-x |
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