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Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts
Adult newts can regenerate large parts of their brain from adult neural stem cells (NSCs), but how adult NSCs reorganize brain structures during regeneration remains unclear. In development, elaborate brain structures are produced under broadly coordinated regulations of embryonic NSCs in the neural...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031346/ https://www.ncbi.nlm.nih.gov/pubmed/29903864 http://dx.doi.org/10.1242/bio.033142 |
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author | Urata, Yuko Yamashita, Wataru Inoue, Takeshi Agata, Kiyokazu |
author_facet | Urata, Yuko Yamashita, Wataru Inoue, Takeshi Agata, Kiyokazu |
author_sort | Urata, Yuko |
collection | PubMed |
description | Adult newts can regenerate large parts of their brain from adult neural stem cells (NSCs), but how adult NSCs reorganize brain structures during regeneration remains unclear. In development, elaborate brain structures are produced under broadly coordinated regulations of embryonic NSCs in the neural tube, whereas brain regeneration entails exquisite control of the re-establishment of certain brain parts, suggesting that a yet-unknown mechanism directs NSCs upon partial brain excision. Here we report that upon excision of a quarter of the adult newt (Pleurodeles waltl) mesencephalon, active participation of local NSCs around specific brain subregions’ boundaries leads to some imperfect and some perfect brain regeneration along an individual's rostrocaudal axis. Regeneration phenotypes depend on how wound closing occurs using local NSCs, and perfect regeneration replicates development-like processes, but takes more than 1 year. Our findings indicate that newt brain regeneration is supported by modularity of boundary-domain NSCs with self-organizing ability in neighboring fields. This article has an associated First Person interview with the first author of the paper. |
format | Online Article Text |
id | pubmed-6031346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60313462018-07-06 Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts Urata, Yuko Yamashita, Wataru Inoue, Takeshi Agata, Kiyokazu Biol Open Research Article Adult newts can regenerate large parts of their brain from adult neural stem cells (NSCs), but how adult NSCs reorganize brain structures during regeneration remains unclear. In development, elaborate brain structures are produced under broadly coordinated regulations of embryonic NSCs in the neural tube, whereas brain regeneration entails exquisite control of the re-establishment of certain brain parts, suggesting that a yet-unknown mechanism directs NSCs upon partial brain excision. Here we report that upon excision of a quarter of the adult newt (Pleurodeles waltl) mesencephalon, active participation of local NSCs around specific brain subregions’ boundaries leads to some imperfect and some perfect brain regeneration along an individual's rostrocaudal axis. Regeneration phenotypes depend on how wound closing occurs using local NSCs, and perfect regeneration replicates development-like processes, but takes more than 1 year. Our findings indicate that newt brain regeneration is supported by modularity of boundary-domain NSCs with self-organizing ability in neighboring fields. This article has an associated First Person interview with the first author of the paper. The Company of Biologists Ltd 2018-06-14 /pmc/articles/PMC6031346/ /pubmed/29903864 http://dx.doi.org/10.1242/bio.033142 Text en © 2018. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Urata, Yuko Yamashita, Wataru Inoue, Takeshi Agata, Kiyokazu Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
title | Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
title_full | Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
title_fullStr | Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
title_full_unstemmed | Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
title_short | Spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
title_sort | spatio-temporal neural stem cell behavior leads to both perfect and imperfect structural brain regeneration in adult newts |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031346/ https://www.ncbi.nlm.nih.gov/pubmed/29903864 http://dx.doi.org/10.1242/bio.033142 |
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