Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

Down syndrome (DS) results from triplication of human chromosome 21. Neuropathological hallmarks of DS include atypical central nervous system development that manifests prenatally and extends throughout life. As a result, individuals with DS exhibit cognitive and motor deficits, and have delays in...

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Detalles Bibliográficos
Autores principales: Aziz, Nadine M., Guedj, Faycal, Pennings, Jeroen L. A., Olmos-Serrano, Jose Luis, Siegel, Ashley, Haydar, Tarik F., Bianchi, Diana W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031353/
https://www.ncbi.nlm.nih.gov/pubmed/29716957
http://dx.doi.org/10.1242/dmm.031013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031353/
https://www.ncbi.nlm.nih.gov/pubmed/29716957
http://dx.doi.org/10.1242/dmm.031013

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