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Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits
The genetic causes of cancer include both somatic mutations and inherited germline variants. Large-scale tumor sequencing has revolutionized the identification of somatic driver alterations but has had limited impact on the identification of cancer predisposition genes (CPGs). Here we present a stat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031629/ https://www.ncbi.nlm.nih.gov/pubmed/29973584 http://dx.doi.org/10.1038/s41467-018-04900-7 |