miR-130a and miR-145 reprogram Gr-1(+)CD11b(+) myeloid cells and inhibit tumor metastasis through improved host immunity

Tumor-derived soluble factors promote the production of Gr-1(+)CD11b(+) immature myeloid cells, and TGFβ signaling is critical in their immune suppressive function. Here, we report that miR-130a and miR-145 directly target TGFβ receptor II (TβRII) and are down-regulated in these myeloid cells, leadi...

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Detalles Bibliográficos
Autores principales: Ishii, Hiroki, Vodnala, Suman K., Achyut, Bhagelu R., So, Jae Young, Hollander, M. Christine, Greten, Tim F., Lal, Ashish, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031699/
https://www.ncbi.nlm.nih.gov/pubmed/29973593
http://dx.doi.org/10.1038/s41467-018-05023-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031699/
https://www.ncbi.nlm.nih.gov/pubmed/29973593
http://dx.doi.org/10.1038/s41467-018-05023-9

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