Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects

A series of new fluoroquinazolinone 6–8 and 10a–g derivatives was designed, prepared and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and MDA-MBA-231. Compounds 6 (IC(50) = 0.35 ± 0.01 µM), 10f (IC(50) = 0.71 ± 0.01 µM), 10d (IC(50) = 0.89 ± 0.02 µM) and 10a (...

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Detalles Bibliográficos
Autores principales: Zayed, Mohamed F., Ahmed, Sahar, Ihmaid, Saleh, Ahmed, Hany E. A., Rateb, Heba S., Ibrahim, Sabrin R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032053/
https://www.ncbi.nlm.nih.gov/pubmed/29891789
http://dx.doi.org/10.3390/ijms19061731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032053/
https://www.ncbi.nlm.nih.gov/pubmed/29891789
http://dx.doi.org/10.3390/ijms19061731

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