Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety

Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreira, Rute, Pereira, David M., Valentão, Patrícia, Andrade, Paula B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032134/
https://www.ncbi.nlm.nih.gov/pubmed/29874826
http://dx.doi.org/10.3390/ijms19061668
_version_ 1783337443515170816
author Moreira, Rute
Pereira, David M.
Valentão, Patrícia
Andrade, Paula B.
author_facet Moreira, Rute
Pereira, David M.
Valentão, Patrícia
Andrade, Paula B.
author_sort Moreira, Rute
collection PubMed
description Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA.
format Online
Article
Text
id pubmed-6032134
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60321342018-07-13 Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety Moreira, Rute Pereira, David M. Valentão, Patrícia Andrade, Paula B. Int J Mol Sci Review Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA. MDPI 2018-06-05 /pmc/articles/PMC6032134/ /pubmed/29874826 http://dx.doi.org/10.3390/ijms19061668 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moreira, Rute
Pereira, David M.
Valentão, Patrícia
Andrade, Paula B.
Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_full Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_fullStr Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_full_unstemmed Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_short Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
title_sort pyrrolizidine alkaloids: chemistry, pharmacology, toxicology and food safety
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032134/
https://www.ncbi.nlm.nih.gov/pubmed/29874826
http://dx.doi.org/10.3390/ijms19061668
work_keys_str_mv AT moreirarute pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
AT pereiradavidm pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
AT valentaopatricia pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety
AT andradepaulab pyrrolizidinealkaloidschemistrypharmacologytoxicologyandfoodsafety

Ejemplares similares