NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway

NSC 95397, a quinone-based small molecule compound, has been identified as an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). MKP-1 is known to inactivate mitogen-activated protein kinases by dephosphorylating both of their threonine and...

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Detalles Bibliográficos
Autores principales: Dubey, Navneet Kumar, Peng, Bou-Yue, Lin, Chien-Min, Wang, Peter D., Wang, Joseph R., Chan, Chun-Hao, Wei, Hong-Jian, Deng, Win-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032145/
https://www.ncbi.nlm.nih.gov/pubmed/29857489
http://dx.doi.org/10.3390/ijms19061625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032145/
https://www.ncbi.nlm.nih.gov/pubmed/29857489
http://dx.doi.org/10.3390/ijms19061625

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