Presenilins as Drug Targets for Alzheimer’s Disease—Recent Insights from Cell Biology and Electrophysiology as Novel Opportunities in Drug Development

A major cause underlying familial Alzheimer’s disease (AD) are mutations in presenilin proteins, presenilin 1 (PS1) and presenilin 2 (PS2). Presenilins are components of the γ-secretase complex which, when mutated, can affect amyloid precursor protein (APP) processing to toxic forms of amyloid beta...

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Detalles Bibliográficos
Autores principales: Duncan, R. Scott, Song, Bob, Koulen, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032171/
https://www.ncbi.nlm.nih.gov/pubmed/29857474
http://dx.doi.org/10.3390/ijms19061621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032171/
https://www.ncbi.nlm.nih.gov/pubmed/29857474
http://dx.doi.org/10.3390/ijms19061621

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