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The Crystal Structure of a hCA VII Variant Provides Insights into the Molecular Determinants Responsible for Its Catalytic Behavior

Although important progress has been achieved in understanding the catalytic mechanism of Carbonic Anhydrases, a detailed picture of all factors influencing the catalytic efficiency of the various human isoforms is still missing. In this paper we report a detailed structural study and theoretical pK...

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Detalles Bibliográficos
Autores principales: Buonanno, Martina, Di Fiore, Anna, Langella, Emma, D’Ambrosio, Katia, Supuran, Claudiu T., Monti, Simona Maria, De Simone, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032174/
https://www.ncbi.nlm.nih.gov/pubmed/29795045
http://dx.doi.org/10.3390/ijms19061571