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A peptide‐display protein scaffold to facilitate single molecule force studies of aggregation‐prone peptides

Protein aggregation is linked with the onset of several neurodegenerative disorders, including Parkinson's disease (PD), which is associated with the aggregation of α‐synuclein (αSyn). The structural mechanistic details of protein aggregation, including the nature of the earliest protein–protei...

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Detalles Bibliográficos
Autores principales: Doherty, Ciaran P. A., Young, Lydia M., Karamanos, Theodoros K., Smith, Hugh I., Jackson, Matthew P., Radford, Sheena E., Brockwell, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032367/
https://www.ncbi.nlm.nih.gov/pubmed/29417650
http://dx.doi.org/10.1002/pro.3386