Extension of Tissue Plasminogen Activator Treatment Window by Granulocyte-Colony Stimulating Factor in a Thromboembolic Rat Model of Stroke

When given beyond 4.5 h of stroke onset, tissue plasminogen activator (tPA) induces deleterious side effects in the ischemic brain, notably, hemorrhagic transformation (HT). We examined the efficacy of granulocyte-colony stimulating factor (G-CSF) in reducing delayed tPA-induced HT, cerebral infarct...

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Detalles Bibliográficos
Autores principales: dela Peña, Ike C., Yang, Samuel, Shen, Guofang, Fang Liang, Hsiao, Solak, Sara, Borlongan, Cesar V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032420/
https://www.ncbi.nlm.nih.gov/pubmed/29857523
http://dx.doi.org/10.3390/ijms19061635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032420/
https://www.ncbi.nlm.nih.gov/pubmed/29857523
http://dx.doi.org/10.3390/ijms19061635

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