Cargando…

Loss of N‐WASP drives early progression in an Apc model of intestinal tumourigenesis

N‐WASP (WASL) is a widely expressed cytoskeletal signalling and scaffold protein also implicated in regulation of Wnt signalling and homeostatic maintenance of skin epithelial architecture. N‐WASP mediates invasion of cancer cells in vitro and its depletion reduces invasion and metastatic disseminat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morris, Hayley T, Fort, Loic, Spence, Heather J, Patel, Rachana, Vincent, David F, Park, James H, Snapper, Scott B, Carey, Francis A, Sansom, Owen J, Machesky, Laura M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2018
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033012/ https://www.ncbi.nlm.nih.gov/pubmed/29672847 http://dx.doi.org/10.1002/path.5086

Ejemplares similares

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium
por: Cole, Alicia M, et al.
Publicado: (2010)

A RAC-GEF network critical for early intestinal tumourigenesis
por: Pickering, K. A., et al.
Publicado: (2021)

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis
por: Ahmad, I, et al.
Publicado: (2011)

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
por: Flanagan, Dustin J., et al.
Publicado: (2022)

Mbd2 enables tumourigenesis within the intestine while preventing tumour‐promoting inflammation
por: May, Stephanie, et al.
Publicado: (2018)

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis
por: Nászai, Máté, et al.
Publicado: (2021)

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine
por: Reed, Karen R, et al.
Publicado: (2008)

Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
por: Flanagan, Dustin J., et al.
Publicado: (2023)

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis
por: Cammareri, Patrizia, et al.
Publicado: (2017)

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
por: Gudiño, Victoria, et al.
Publicado: (2021)

ERK activation drives intestinal tumorigenesis in Apc(min/)(+) mice
por: Lee, Sung Hee, et al.
Publicado: (2010)

Systemic muscle wasting and coordinated tumour response drive tumourigenesis
por: Newton, Holly, et al.
Publicado: (2020)

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation
por: Foth, Mona, et al.
Publicado: (2018)

N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis
por: Juin, Amelie, et al.
Publicado: (2019)

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice via activation of Wnt and ERK1/2 MAPK pathways
por: Wilson, CH, et al.
Publicado: (2010)

Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition
por: van Driel, Milou S., et al.
Publicado: (2023)

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis
por: Christie, M, et al.
Publicado: (2013)

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
por: Gay, David M., et al.
Publicado: (2019)

Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
por: Chan, Jia Jia, et al.
Publicado: (2022)

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
por: Gay, David M., et al.
Publicado: (2019)

PADI4 and tumourigenesis
por: Chang, Xiaotian, et al.
Publicado: (2010)

The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis
por: Ritchie, Shona, et al.
Publicado: (2021)

HES5 silencing is an early and recurrent change in prostate tumourigenesis
por: Massie, Charles E, et al.
Publicado: (2015)

Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier
por: Garber, John J., et al.
Publicado: (2017)

Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis
por: Greenow, Kirsty R., et al.
Publicado: (2018)

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
por: Dikovskaya, Dina, et al.
Publicado: (2007)

BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
por: Loveridge, Carolyn J., et al.
Publicado: (2019)

Cancer Stemness in Apc- vs. Apc/KRAS-Driven Intestinal Tumorigenesis
por: Ghazvini, Mehrnaz, et al.
Publicado: (2013)

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes
por: Méniel, Valérie, et al.
Publicado: (2014)

c-Src drives intestinal regeneration and transformation
por: Cordero, Julia B, et al.
Publicado: (2014)

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing
por: Tian, Ai, et al.
Publicado: (2017)

Brg1 Loss Attenuates Aberrant Wnt-Signalling and Prevents Wnt-Dependent Tumourigenesis in the Murine Small Intestine
por: Holik, Aliaksei Z., et al.
Publicado: (2014)

Rac1 drives intestinal stem cell proliferation and regeneration
por: Myant, Kevin B, et al.
Publicado: (2013)

Correction: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
por: Loveridge, Carolyn J., et al.
Publicado: (2019)

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc(Min/+ )mouse small intestine
por: Patek, Charles E, et al.
Publicado: (2008)

N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism
por: Wang, Yanying, et al.
Publicado: (2021)

MET Exon 14 Splice-Site Mutations Preferentially Activate KRAS Signaling to Drive Tumourigenesis
por: Lu, Daniel, et al.
Publicado: (2022)

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis
por: Biswas, Amlan, et al.
Publicado: (2018)

Contribution of the KSHV and EBV lytic cycles to tumourigenesis
por: Manners, Oliver, et al.
Publicado: (2018)

Spontaneous Tumourigenesis in Aged Guinea-pigs
por: Lipschutz, A., et al.
Publicado: (1959)

Cannot write session to /tmp/vufind_sessions/sess_ch4p8dp6f263eln5pkbvm587iu