Cargando…

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury

Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases. PTOA leads to reduced physical activity, deconditio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Jiun C, Christiansen, Blaine A, Murugesh, Deepa K, Sebastian, Aimy, Hum, Nicholas R, Collette, Nicole M, Hatsell, Sarah, Economides, Aris N, Blanchette, Craig D, Loots, Gabriela G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033030/ https://www.ncbi.nlm.nih.gov/pubmed/29377313 http://dx.doi.org/10.1002/jbmr.3397

Ejemplares similares

Global molecular changes in a tibial compression induced ACL rupture model of post‐traumatic osteoarthritis
por: Chang, Jiun C., et al.
Publicado: (2016)

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression
por: Sebastian, Aimy, et al.
Publicado: (2018)

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner()
por: Collette, Nicole M., et al.
Publicado: (2013)

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts
por: Sebastian, Aimy, et al.
Publicado: (2017)

SOST Inhibits Prostate Cancer Invasion
por: Hudson, Bryan D., et al.
Publicado: (2015)

Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis
por: Rios‐Arce, Naiomy D, et al.
Publicado: (2022)

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes
por: Sebastian, Aimy, et al.
Publicado: (2021)

Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer
por: Sebastian, Aimy, et al.
Publicado: (2015)

Antibiotic Treatment Prior to Injury Improves Post-Traumatic Osteoarthritis Outcomes in Mice
por: Mendez, Melanie E., et al.
Publicado: (2020)

LPS‐Induced Inflammation Prior to Injury Exacerbates the Development of Post‐Traumatic Osteoarthritis in Mice
por: Mendez, Melanie E, et al.
Publicado: (2020)

Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice
por: Donham, Cristine, et al.
Publicado: (2021)

Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice
por: Sebastian, Aimy, et al.
Publicado: (2020)

Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis
por: Sebastian, Aimy, et al.
Publicado: (2022)

Antibiotic Treatment Prior to Injury Abrogates the Detrimental Effects of LPS in STR/ort Mice Susceptible to Osteoarthritis Development
por: Mendez, Melanie E, et al.
Publicado: (2023)

Expression of SOST/sclerostin in compressed periodontal ligament cells
por: Ueda, Masae, et al.
Publicado: (2016)

Suppression of Sost/Sclerostin and Dickkopf‐1 Augment Intervertebral Disc Structure in Mice
por: Kroon, Tori, et al.
Publicado: (2022)

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo
por: Basha, Genc, et al.
Publicado: (2016)

Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene
por: Cao, Yanming, et al.
Publicado: (2019)

Parathyroid Hormone (PTH)–Induced Bone Gain Is Blunted in SOST Overexpressing and Deficient Mice
por: Kramer, Ina, et al.
Publicado: (2010)

DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
por: Papathanasiou, Ioanna, et al.
Publicado: (2015)

Global Gene Expression Analysis of Murine Limb Development
por: Taher, Leila, et al.
Publicado: (2011)

Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling
por: Grimston, Susan K., et al.
Publicado: (2017)

Genetic Deletion of Sost or Pharmacological Inhibition of Sclerostin Prevent Multiple Myeloma-induced Bone Disease without Affecting Tumor Growth
por: Delgado-Calle, Jesus, et al.
Publicado: (2017)

SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone
por: Li, Jingyu, et al.
Publicado: (2019)

Degradation‐Resistant Hypoxia Inducible Factor‐2α in Murine Osteocytes Promotes a High Bone Mass Phenotype
por: Mendoza, Sarah V., et al.
Publicado: (2023)

Prostaglandin E(2) Signals Through PTGER2 to Regulate Sclerostin Expression
por: Genetos, Damian C., et al.
Publicado: (2011)

Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data
por: Rios‐Arce, Naiomy D., et al.
Publicado: (2022)

Relationship Between Sclerostin (SOST) Expression and Genetic Loci rs851056, rs1230399 Polymorphisms and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes in Xinjiang
por: Li, Jun, et al.
Publicado: (2021)

Sclerostin expression in the subchondral bone of patients with knee osteoarthritis
por: Wu, Long, et al.
Publicado: (2016)

Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice
por: Malfatti, Michael A., et al.
Publicado: (2020)

The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva
por: Wolken, Dana M. Alessi, et al.
Publicado: (2017)

A Novel Mutation in SOST Gene Causes Sclerosteosis
por: Alyusuf, Ebtihal Y, et al.
Publicado: (2021)

S281: TMPRSS6 INHIBITION WITH A MONOCLONAL ANTIBODY IMPROVES RED BLOOD CELL HEALTH AND IRON OVERLOAD IN A MOUSE MODEL OF BETA-THALASSEMIA
por: Lob, Heinrich, et al.
Publicado: (2023)

Sclerostin
por: Silverman, Stuart L.
Publicado: (2010)

Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In Vivo
por: Bullock, Whitney A., et al.
Publicado: (2019)

Anatomical similarity between the Sost‐knockout mouse and sclerosteosis in humans
por: Schwarze, Uwe Y., et al.
Publicado: (2019)

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling
por: van Dinther, Maarten, et al.
Publicado: (2013)

Sost Deficiency does not Alter Bone’s Lacunar or Vascular Porosity in Mice
por: Mosey, Henry, et al.
Publicado: (2017)

EFFECT OF PKP ON SERUM SOST IN PATIENTS WITH VERTEaBRAL COMPRESSION FRACTURES
por: WANG, ENZHI, et al.
Publicado: (2020)

Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts
por: Martínez-Gil, Núria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ng1bm6a9h2q642pdgbmqrae79v