7‐Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir

Dolutegravir (DTG), an important active pharmaceutical ingredient (API) used in combination therapy for the treatment of HIV, has been synthesized in continuous flow. By adapting the reported GlaxoSmithKline process chemistry batch route for Cabotegravir, DTG was produced in 4.5 h in sequential flow...

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Detalles Bibliográficos
Autores principales: Ziegler, Robert E., Desai, Bimbisar K., Jee, Jo‐Ann, Gupton, B. Frank, Roper, Thomas D., Jamison, Timothy F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033037/
https://www.ncbi.nlm.nih.gov/pubmed/29756689
http://dx.doi.org/10.1002/anie.201802256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033037/
https://www.ncbi.nlm.nih.gov/pubmed/29756689
http://dx.doi.org/10.1002/anie.201802256

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