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Degradation or aggregation: the ramifications of post-translational modifications on tau

Tau protein is encoded in the microtubule-associated protein tau (MAPT) gene and contributes to the stability of microtubules in axons. Despite of its basic isoelectric point and high solubility, tau is often found in intraneuronal filamentous inclusions such as paired helical filaments (PHFs), whic...

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Detalles Bibliográficos
Autores principales: Park, Seoyoung, Lee, Jung Hoon, Jeon, Jun Hyoung, Lee, Min Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033068/
https://www.ncbi.nlm.nih.gov/pubmed/29661268
http://dx.doi.org/10.5483/BMBRep.2018.51.6.077