Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics

To identify the genetic basis of interindividual variability in montelukast exposure, we determined its pharmacokinetics and sequenced 379 pharmacokinetic genes in 191 healthy volunteers. An intronic single nucleotide variation (SNV), strongly linked with UGT1A3*2, associated with reduced area under...

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Detalles Bibliográficos
Autores principales: Hirvensalo, Päivi, Tornio, Aleksi, Neuvonen, Mikko, Tapaninen, Tuija, Paile‐Hyvärinen, Maria, Kärjä, Vesa, Männistö, Ville T., Pihlajamäki, Jussi, Backman, Janne T., Niemi, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033076/
https://www.ncbi.nlm.nih.gov/pubmed/28940478
http://dx.doi.org/10.1002/cpt.891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033076/
https://www.ncbi.nlm.nih.gov/pubmed/28940478
http://dx.doi.org/10.1002/cpt.891

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