Highly Selective Directed Iridium‐Catalyzed Hydrogen Isotope Exchange Reactions of Aliphatic Amides

For the first time, we describe highly selective homogeneous iridium‐catalyzed hydrogen isotope exchange (HIE) of unactivated C(sp(3)) centers in aliphatic amides. When using the commercially available Kerr catalyst, the HIE with a series of common antibody–drug conjugate (ADC) linker side chains pr...

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Detalles Bibliográficos
Autores principales: Valero, Mégane, Weck, Remo, Güssregen, Stefan, Atzrodt, Jens, Derdau, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033151/
https://www.ncbi.nlm.nih.gov/pubmed/29693316
http://dx.doi.org/10.1002/anie.201804010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033151/
https://www.ncbi.nlm.nih.gov/pubmed/29693316
http://dx.doi.org/10.1002/anie.201804010

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