BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells

Melanoma is the most dangerous form of skin cancer with a growing incidence over the last decades. Fourty percent of all melanomas harbor a mutation in the signaling adaptor BRAF (V600E) that results in ERK hyperactivity as an oncogenic driver. In these cases, treatment with the BRAF(V600E) inhibito...

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Detalles Bibliográficos
Autores principales: Hajek, Eva, Krebs, Franziska, Bent, Rebekka, Haas, Katharina, Bast, Antje, Steinmetz, Ivo, Tuettenberg, Andrea, Grabbe, Stephan, Bros, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033361/
https://www.ncbi.nlm.nih.gov/pubmed/29983861
http://dx.doi.org/10.18632/oncotarget.25511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033361/
https://www.ncbi.nlm.nih.gov/pubmed/29983861
http://dx.doi.org/10.18632/oncotarget.25511

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